merck millipore,默克密理愽
  • merck millipore,默克密理博,480457,NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem

  • merck millipore,默克密理博,480457,NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem

    产品名称：NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem
    产品型号：480457
    The NF-κB Activation Inhibitor VII, CID-2858522 controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,480457,NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,480457,NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem

    重要规格表

    经验配方
    C₂₈H₃₉N₃O₃
    描述
    概述 A cell-permeable selective inhibitor of NF-κB activation induced by PKC pathway activators such as PMA (IC50 = 70 nM) in a HEK293 cell-based NF-κB luciferase reporter gene assay, by operating downstream of PKC but upstream of IKKβ, without inhibiting other NF-κB activation pathways. At 10 µM, this compound only inhibits Raf, TLK1, and JAK2 by 57%, 70%, and 53%, respectively, among a panel of 353 protein kinases. In addition, it attenuates CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T-cells (IC50 < 5 µM) and anti-IgM-stimulated proliferation of murine B-lymphocytes (IC50 = 2 µM).
    产品目录编号 480457
    品牌系列 Calbiochem®
    同义词 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone; CID-2858522; 2-aminobenzimidazole; Compound 1a
    参考
    参考 Peddibhotla, S., et al. 2010. J. Med. Chem. 53, 4793.
    产品信息
    形式 Off-white powder
    Hill配方 C₂₈H₃₉N₃O₃
    化学配方 C₂₈H₃₉N₃O₃
    Molar Mass 465.63
    结构配方图像
    生物信息
    纯度 >95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,480457,NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem

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