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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, M ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS245 描述 Anti-PKM2 Antibody Alternate Names - p58
- Embryonic enzyme pyruvate kinase M2
- Pyruvate kinase isozymes M1/M2
- Cytosolic thyroid hormone-binding protein
- CTHBP
- Opa-interacting protein 3
- OIP-3
- Pyruvate kinase 2/3
- Pyruvate kinase muscle isozyme
- Thyroid hormone-binding protein 1
- THBP1
- Tumor M2-PK
背景信息 Pyruvate kinase isozymes M1/M2 (PKM2) is also called Cytosolic thyroid hormone-binding protein (CTHBP), Opa-interacting protein 3 (OIP-3), Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1 (THBP1) and p58. PKM2 is a glycolytic enzyme that assists in generating ATP. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. This control of glycolysis and is important for tumor cell proliferation and survival. PKM2 is specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, and cancer cells. 产品信息 格式 Affinity Purified 控制 - P19 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PKM2 Antibody is a highly specific rabbit polyclonal antibody, that targets Pyruvate Kinase & has been tested in western blotting & ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected PKM2 in HeLa cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human PKM2 near the C-terminus. 表位 Near C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes PKM2 near the C-terminus. 品种反应性 MonkeyHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Monkey. Predicted to react with Rat, Bovine, and Horse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_872270
基因符号 - PKM2
- PKM
- OIP3
- PK2
- PK3
纯化方法 Affinity purified UniProt编号 - P14618
产品使用声明 质量保证 Evaluated by Western Blotting in P19 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected PKM2 in 10 µg of P19 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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