merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1522,Anti-hnRNP A2/B1 Antibody, clone DP383

  • merck millipore,默克密理博,05-1522,Anti-hnRNP A2/B1 Antibody, clone DP383

    产品名称：Anti-hnRNP A2/B1 Antibody, clone DP383
    产品型号：05-1522
    Use Anti-hnRNP A2/B1 Antibody, clone DP383 (Mouse Monoclonal Antibody) validated in WB, IHC, IP to detect hnRNP A2/B1 also known as heterogeneous nuclear ribonucleoprotein A2/B1.

    merck millipore,默克密理博,05-1522,Anti-hnRNP A2/B1 Antibody, clone DP383

  • 产品介绍
  • merck millipore,默克密理博,05-1522,Anti-hnRNP A2/B1 Antibody, clone DP383

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1522
    描述 Anti-hnRNP A2/B1 Antibody, clone DP383
    Alternate Names
    • nuclear ribonucleoprotein particle A2 protein
    • heterogeneous nuclear ribonucleoprotein A2/B1
    • heterogeneous nuclear ribonucleoprotein B1
    • hnRNP A2 / hnRNP B1
    背景信息 The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and associate with pre-mRNAs in the nucleus. These complexes are associated with pre-mRNA processing and other aspects of mRNA metabolism and transport. While all hnRNPs are present in the nucleus, data suggests they shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by hnRNP A2/B1 belongs to the A/B subfamily of ubiquitously express hnRNPs. This family member has two repeats of quasi-RRM domains that bind to RNAs. Two alternatively spliced transcript variants which encode different isoforms have been described. In autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease hnRNPA2B1 can serve as an autoantigen. Although this protein is predominantly nucleoplasmic, in some tissues isoform A2 is found in the cytoplasm.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Use Anti-hnRNP A2/B1 Antibody, clone DP383 (Mouse Monoclonal Antibody) validated in WB, IHC, IP to detect hnRNP A2/B1 also known as heterogeneous nuclear ribonucleoprotein A2/B1.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry:
    Cited in Mizukami, K., et al. (2000) Neuroreport. 11(14):3099-102 using a representative lot of this antibody.
    Immunoprecipitation:
    Cited in Kamma, H., et al. (1999) Exp. Cell Res. 246(2):399-411using a representative lot of this antibody.
    生物信息
    免疫原品种 Recombinant protein corresponding to human hnRNP A2/B1.
    表位 Unknown
    克隆 DP383
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes hnRNP A2/B1.
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002128
    Entrez基因汇总 This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq].
    基因符号
    • HNRNPA2B1
    • HNRNPA2
    • HNRNPB1
    • HNRPA2
    • HNRPA2B1
    • HNRPB1
    • RNPA2
    • SNRPB1
    纯化方法 Protein G purfied
    UniProt编号
    • P22626
    UniProt汇总 FUNCTION: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous.

    SUBUNIT STRUCTURE: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1.

    SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus. Ref.15

    SEQUENCE SIMILARITIES: Contains 2 RRM (RNA recognition motif) domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: 0.5 µg/ml of this antibody detected hnRNP A2/B1 on 10 µg of HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1522,Anti-hnRNP A2/B1 Antibody, clone DP383

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