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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-822 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-eIF2Bε (Ser539) Antibody 产品信息 格式 Affinity Purified 应用 应用 Anti-phospho-eIF2Bε (Ser539) Antibody is an antibody against phospho-eIF2Bε (Ser539) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser539 of human eIF2Bε 宿主 Rabbit 特异性 Recognizes eIFB2ε phosphorylated on Ser539. 同种型 IgG 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003907.2
基因符号 - CACH
- EIF2B5
- EIF-2B
- EIF2Bepsilon
- LVWM
- EIF2BE
- CLE
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - Q13144
UniProt汇总 FUNCTION: SwissProt: Q13144 # Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
SIZE: 721 amino acids; 80380 Da
SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
DISEASE: SwissProt: Q13144 # Defects in EIF2B5 are a cause of leukoencephalopathy with vanishing white matter (VWM) [MIM:603896]. VWM is a brain disease that occurs mainly in children. The neurological signs of VWM include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. Head trauma leads only to motor deterioration, whereas infections with fever may end in coma. Death occurs after a variable period of a few years to a few decades, usually following an episode of fever and coma. & Defects in EIF2B5 are a cause of ovarioleukodystrophy [MIM:603896]; also known as vanishing white matter leukodystrophy with ovarian failure. It is a condition of ovarian failure associated with cerebral abnormalities similar to those in patients with vanishing white matter leukodystrophy. & Defects in EIF2B5 are a cause of Cree leukoencephalopathy (CLE) [MIM:603896]. CLE is a rapidly fatal infantile autosomal recessive leukodystrophy that is observed in the native Cree and Chippewayan indigenous population of northern Quebec and Manitoba.
SIMILARITY: SwissProt: Q13144 ## Belongs to the EIF-2B gamma/epsilon subunits family.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,407135,Caged Ins(1,4,5)P₃, Trisodium Salt - Calbiochem
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