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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN646 描述 Anti-SCRAPPER Antibody Alternate Names - F-box/LRR-repeat protein 2-like
- F-box/LRR-repeat protein 20
- F-box and leucine-rich repeat protein 20
背景信息 F-box/LRR-repeat protein 20, also known as F-box and leucine-rich repeat protein 20 or F-box/LRR-repeat protein 2-like, and encoded by the gene name FBXL20 or FBL2 contain 13 LRR (leucine-rich) repeats. Members of the F-box protein family, such as SCRAPPER, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. SCRAPPER is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. SCRAPPER has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. SCRAPPER is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasomesystem (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect SCRAPPER using this Anti-SCRAPPER Antibody validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected SCRAPPER in human brain tissue. 生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the N-terminus of human SCRAPPER. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - FBL2
- FBXL20
纯化方法 Antigen Affinity purified UniProt编号 - Q96IG2
产品使用声明 质量保证 Evaluated by Western Blotting in A20 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected SCRAPPER in A20 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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