merck millipore,默克密理博,07-938,Anti-HNF-3A/ FOXA1 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	ICC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-938
描述	Anti-HNF-3A/ FOXA1 Antibody
Alternate Names	hepatocyte nuclear factor 3, alpha Forkhead box protein A1 forkhead box A1
背景信息	HNF-3A, Hepatocyte nuclear factor 3-alpha (also called FOXA1) is member of the Forkhead family of winged-helix transcription factors. This protein family has around 50 known transcription factors and play an important role in the regulation of cell differentiation, organogenesis, and gene expression. High levels of expression of HNF-3A has been observed in tumors arising from both the prostate and breast. Here it is believed this protein interacts with the androgen receptor in prostate tumors and the estrogen receptor α in breast tumors. In the case of ERα, HNF-3A interacts with cis-regulatory regions in heterochromatin and enhances the interaction of ERα with chromatin.

产品信息
格式	Affinity Purified
控制	Human pancreas tissue lysate
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

应用
应用	Anti-HNF-3A/ FOXA1 Antibody is a Rabbit Polyclonal Antibody for detection of HNF-3A/ FOXA1 also known as Forkhead box protein A1, hepatocyte nuclear factor 3 alpha & has been validated in WB, ICC.
主要应用	Immunocytochemistry Western Blotting
应用说明	Western Blot (SNAP ID) Analysis: 1 µg/ml from a representative lot detected HNF-3A/FOXA1 on 10 µg of human pancreas tissue lysate. Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected HNF-3A/FOXA1 in NIH/3T3 and HeLa cells.

生物信息
免疫原品种	Recombinant protein corresponding to the entire protein of human HNF-3A/FOXA1.
表位	Entire protein
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes HNF-3A/FOXA1.
品种反应性	MouseHuman
Species Reactivity Note	Demonstrated to react with human and mouse. Homology to Chimpanzee is 96%. Homology to canine is 94%.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_004487
Entrez基因汇总	This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq].
基因符号	MGC33105 FOXA1 HNF-3-alpha HNF-3A HNF3A TCF3A
纯化方法	Affinity Purfied
UniProt编号	P55317
UniProt汇总	FUNCTION: Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain.

产品使用声明
质量保证	Evaluated by Western Blot in human pancreas tissue lysate. Western Blot Analysis: 0.5 µg/ml of this antibody detected HNF-3A/FOXA1 on 10 µg of human pancreas tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,07-938,Anti-HNF-3A/ FOXA1 Antibody

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