merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1554,Anti-Nerve Growth Factor Receptor Antibody, p75

  • merck millipore,默克密理博,AB1554,Anti-Nerve Growth Factor Receptor Antibody, p75

    产品名称：Anti-Nerve Growth Factor Receptor Antibody, p75
    产品型号：AB1554
    Anti-Nerve Growth Factor Receptor Antibody, p75 is an antibody against Nerve Growth Factor Receptor for use in IC, IH(P), and IP.

    merck millipore,默克密理博,AB1554,Anti-Nerve Growth Factor Receptor Antibody, p75

  • 产品介绍
  • merck millipore,默克密理博,AB1554,Anti-Nerve Growth Factor Receptor Antibody, p75

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB1554
    Replaces 04-1111
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nerve Growth Factor Receptor Antibody, p75
    Alternate Names
    • p75 ICD
    • CD271 antigen
    • Low affinity neurotrophin receptor p75NTR
    • Low-affinity nerve growth factor receptor
    • NGF receptor
    • low affinity nerve growth factor receptor
    • nerve growth factor receptor
    • nerve growth factor receptor (TNFR superfamily, member 16)
    • member 16)
    背景信息 Nerve Growth Factor Receptor, also termed NGFR p75, p75NTR, or CD271 is the low affinity NGFR (LNGFR) which binds NGF and other neurotrophins including BDNF, NT3, NT4/5 with similar, low affinity. NGFR p75 is a 75 kDa transmembrane glycoprotein (399 a.a.) consisting of an extracellular domain (222 a.a.) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 a.a.), and a cytoplasmic domain (155 a.a.). NGFR p75 is mainly expressed in Schwann cells and neurons and in a variety of non neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS.
    产品信息
    格式 Serum
    控制
    • Rat PC12 cells.
    演示 Rabbit polyclonal serum containing 0.05% NaN3.
    应用
    应用 Anti-Nerve Growth Factor Receptor Antibody, p75 is an antibody against Nerve Growth Factor Receptor for use in IC, IH(P), and IP.
    主要应用
    • Immunocytochemistry
    应用说明 Immunoprecipitation:
    1:500 - 1:5000 dilution of this antibody immunoprecipitated NGF Receptor p75 from 10 µg of PC12 cell lysate.

    Immunohistochemistry(paraffin):
    1:50 and 1:300 dilution from a previous lot detected NGF Receptor p75 using IHC-Select Detection with HRP-DAB.

    Immunocytochemistry:
    1:500 dilution from a previous lot detected NGF Receptor p75 in rat PC12 cells.
    生物信息
    免疫原品种 Recombinant mouse NGF Receptor p75 extracellular fragment.
    表位 extracellular
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 p75 nerve growth factor receptor (p75 Neurotrophin receptor, low affinity neurotrophin receptor), extracellular domain.
    品种反应性 RatHumanMouse
    Species Reactivity Note It has been reported that this antibody does not recognize rat p75 by Western blot. See MAB365 for rat reactive antibody using Western blotting.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_150086.2
    Entrez基因汇总 Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
    基因符号
    • CD271
    • NGFR
    • p75(NTR)
    • TNFRSF16
    • Gp80-LNGFR
    纯化方法 Unpurified
    UniProt编号
    • Q9Z0W1
    UniProt汇总 FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    SIZE: 427 amino acids; 45183 Da
    SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.
    PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.
    SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
    产品使用声明
    质量保证 Routinely evaluated by immunoprecipitation on PC12 cell lysates.

    Immunoprecipitation (IP): 1:500 - 1:5000 dilution of this antibody immunoprecipitated NGF Receptor p75 from 10 µg of PC12 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1554,Anti-Nerve Growth Factor Receptor Antibody, p75

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