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品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN31 描述 Anti-Rhes Antibody Alternate Names - Tumor endothelial marker 2
- GTP-binding protein Rhes
- Ras homolog enriched in striatum
背景信息 Ras family proteins are molecular switches, which are mediated by extracellular signals and regulate intracellular signaling pathways, thereby controlling a plethora of biological functions such as cell growth, gene transcription, mRNA stability and translation, cytoskeleton organization, peptide trafficking and secrection. Ras proteins are also involved in synaptic plasticity, learning, and memory in the central nervous system.
As a member of the RASD subfamily of the Ras-related GTP-binding protein superfamily, Rhes is predominantly expressed in the striatal region of the brain, where it reported to influence brain development and function. It is thought that the activation and expression of the Rhes gene is mediated by thyroid hormones in the brain. In humans, a lack of such hormones is known to cause cretinism. Additionally, Rhes -/- knockout mice display marked behavioral abnormalities, a gender-dependent increase in anxiety levels, and a clear deficit in motor coordination.产品信息 格式 Affinity Purified 控制 - Human pancreas tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Rhes Antibody detects level of Rhes & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Rhes in paraffin-embeded human pancreas cells.
Western Blot Analysis: A representative lot was used by an independent laboratory in HeLa cell extracts, and in mouse striatum protein extracts.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human Rhes. 表位 C-terminus. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of Rhes. 品种反应性 Rhesus MacaqueHumanMouseRat Species Reactivity Note Demonstrated to react with Human, Mouse, Rat. Predicted on Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055125
Entrez基因汇总 This gene encodes a Ras-related protein that is enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. 基因符号 - TEM2
- RASD2
纯化方法 Affinity purified UniProt编号 - Q96D21
UniProt汇总 FUNCTION: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
SUBUNIT STRUCTURE: Monomer Potential. Interacts with PIK3CA and UBE2I By similarity. Interacts with GNB1, GNB2 and GNB3. Interacts with HTT; interacts with mutant HTT (mHTT) with a much higher affinity than wild type HTT.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor.产品使用声明 质量保证 Evaluated by Western Blot in human pancreas tissue lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected Rhes in human pancreas tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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