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描述 产品目录编号 14-462M 品牌系列 Upstate
商名 - Upstate
描述 Rsk3 Protein, active, 250 µg 概述 N-terminal His6-tagged recombinant full-length, human RSK3 应用 应用 Active, N-terminal His6-tagged recombinant full-length, human RSK3, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_021135.4
- NM_001006932.1
Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. 基因符号 - p90-RSK3
- RPS6KA2
- S6K-alpha
- RSK-3
- MAPKAPK1C
- RSK3
- S6K-alpha2
- pp90RSK3
- HU-2
- RSK
蛋白靶 Rsk3 纯化方法 Ni2+/NTA-agarose 靶子系列 AGC UniProt编号 - Q15349
UniProt汇总 FUNCTION: SwissProt: Q15349 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium.
SIZE: 733 amino acids; 83239 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in many tissues. Highest expression in lung and skeletal muscle.
PTM: Autophosphorylated on Ser-377, as part of the activation process (By similarity).
SIMILARITY: SwissProt: Q15349 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.产品使用声明 质量保证 routinely evaluated by phosphorylation of the MAPKAP Kinase 2 substrate peptide 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-462) and in bulk (cat# 14-462-K).
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