merck millipore,默克密理愽
  • merck millipore,默克密理博,110123,Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

  • merck millipore,默克密理博,110123,Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

    产品名称：Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem
    产品型号：110123
    A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties.

    merck millipore,默克密理博,110123,Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,110123,Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₂H₄₈O₅67416-61-9
    描述
    概述 A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
    产品目录编号 110123
    品牌系列 Calbiochem®
    同义词 AKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
    参考
    参考 Syrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
    Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
    Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
    Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
    产品信息
    CAS号 67416-61-9
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₃₂H₄₈O₅
    化学配方 C₃₂H₄₈O₅
    Molar Mass 512.7
    可逆 N
    结构配方图像
    生物信息
    主靶 5-lipoxygenase
    主靶IC50 1.5 µM against 5-lipoxygenase in rat PMNLs
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,110123,Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

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