merck millipore,默克密理愽
  • merck millipore,默克密理博,567809,Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem

  • merck millipore,默克密理博,567809,Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem

    产品名称：Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem
    产品型号：567809
    The Src Inhibitor PP1, also referenced under CAS 172889-26-8, controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati More>>

    merck millipore,默克密理博,567809,Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,567809,Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₉N₅172889-26-8
    描述
    概述 A cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7 µM). Also available in InSolution™ format (Cat. No. 539741).
    产品目录编号 567809
    品牌系列 Calbiochem®
    同义词 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine
    参考
    参考 Ke, J., et.al. 2009. Mol. Cancer 8, 132.
    Sikkema, A.H., et al. 2009. Cancer Res. 69, 5987.
    Bain, J., et al. 2007. Biochem. J. 408, 297.
    Bain, J., et al. 2003. Biochem. J. 371, 199.
    Karni, R., et al. 2003. FEBS Lett. 537, 47.
    Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.
    产品信息
    CAS号 172889-26-8
    形式 Off-white solid
    Hill配方 C₁₆H₁₉N₅
    化学配方 C₁₆H₁₉N₅
    Molar Mass 281.36
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,567809,Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,EZHIPI-17K,Human Intact Proinsulin ELISA
下一件merck millipore产品：merck millipore,默克密理博,681647,WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem


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