merck millipore,默克密理愽
  • merck millipore,默克密理博,681647,WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem

  • merck millipore,默克密理博,681647,WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem

    产品名称：WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem
    产品型号：681647
    The WRN Helicase Inhibitor, NSC 19630, also referenced under CAS 72835-26-8, controls the biological activity of WRN Helicase. This small molecule/inhibitor is primarily used for Cell Signaling applic More>>

    merck millipore,默克密理博,681647,WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,681647,WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₈H₉NO₄72835-26-8
    描述
    概述 A cell-permeable maleimide compound selectively inhibits Werner syndrome WRN helicase activity (IC50 = 20 µM) over its ATPase and exonuclease activities (19% and <10% inhibition, respectively, at 50 µM), while exhibiting no effect against the helicase activity of two other human RecQ family DNA helicases (RECQ1 and Werner syndrome BLM), Fanconi anemia group J helicase FANCJ, as well as three other E. coli helicases, RecQ, UvrD, and DnaB. The WRN-dependent antiproliferation activity of MIRA-1/NSC 19630 in HeLa 1.2.11 cultures (0% vs. 95% inhibition with or without siRNA-mediated WRN-depletion, respectively, after 48 h 3 µM treatment) is shown to be a direct result of apoptosis induction due to replication forks blockage (20-fold increase in PCNA foci staining after 72 h 2 µM treatment), enhanced DSB (17-fold increase in γ-H2AX foci staining after 72 h 2 µM treatment), and increased S-phase population (from 24% to 42% after 72 h 2 µM treatment). In some cells, MIRA-1/NSC 19630 appears to also exert its apoptotic effect, at least in part, by restoring DNA-binding and transactivation function of some, but not all, p53 mutants.
    产品目录编号 681647
    品牌系列 Calbiochem®
    同义词 p53 Activator VIII, 1-((1-Oxopropoxy)methyl)-maleimide, 1-((1-Oxopropoxy)methyl)-1H-pyrrole-2,5-dione, MIRA-1
    参考
    参考 Aggarwal, M., et al. 2011. Proc. Natl. Acad. Sci USA 108, 1525.
    Bykov, V.J.N., et al. 2005. J. Biol. Chem. 280, 30384.
    产品信息
    CAS号 72835-26-8
    形式 White solid
    Hill配方 C₈H₉NO₄
    化学配方 C₈H₉NO₄
    Molar Mass 183.2
    结构配方图像
    生物信息
    纯度 ≥97% by NMR
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,681647,WRN Helicase Inhibitor, NSC 19630 - CAS 72835-26-8 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,567809,Src Inhibitor, PP1 - CAS 172889-26-8 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,648315,Tris Buffer, 100 mM, pH 7.4, Molecular Biology Grade - CAS 77-86-1 - Calbiochem


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