merck millipore,默克密理愽
  • merck millipore,默克密理博,05-118,Anti-FGF-2/basic FGF Antibody, clone bFM-2

  • merck millipore,默克密理博,05-118,Anti-FGF-2/basic FGF Antibody, clone bFM-2

    产品名称：Anti-FGF-2/basic FGF Antibody, clone bFM-2
    产品型号：05-118
    Detect FGF-2/basic FGF using this Anti-FGF-2/basic FGF Antibody, clone bFM-2 validated for use in IH, RIA & WB.

    merck millipore,默克密理博,05-118,Anti-FGF-2/basic FGF Antibody, clone bFM-2

  • 产品介绍
  • merck millipore,默克密理博,05-118,Anti-FGF-2/basic FGF Antibody, clone bFM-2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, B, MWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-118
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-FGF-2/basic FGF Antibody, clone bFM-2
    概述 This antibody can cross-react with native and heat-inactivated basic FGF but will not neutralize biological activity. Upstate recommends anti-FGF-2/basic FGF, neutralizing (Catalog #05-117) for neutralizing activity.
    Alternate Names
    • heparin-binding growth factor 2
    • Basic fibroblast growth factor
    • basic fibroblast growth factor bFGF
    • fibroblast growth factor 2
    • fibroblast growth factor 2 (basic)
    背景信息 FGF basic (FGF2) is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. FGF2 is involved in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. FGF2 mRNA contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
    产品信息
    格式 Purified
    控制
    • Fetal liver or kidney tissue.
    演示 Purified mouse monoclonal IgG1κ in buffer containing PBS, pH 7.4, purified by ammonium sulfate precipitation and DEAE Sephacryl chromatography. Frozen solution.
    应用
    应用 Detect FGF-2/basic FGF using this Anti-FGF-2/basic FGF Antibody, clone bFM-2 validated for use in IH, RIA & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    Previous lots of this antibody have been shown to immunostain frozen brain sections fixed with ice-cold, ethanol:acetic acid [95:5]. This antibody has also been used at 10 μg/mL to stain paraffin-embedded sections (Matsuzaki, K., 1989).
    生物信息
    免疫原品种 Purified bovine brain basic FGF (FGF-2, HBGF-2). Clone bFM-2.
    克隆 bFM-2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody detects FGF-2/basic FGF.
    同种型 IgG1κ
    品种反应性 RatHumanBovineMouse
    Species Reactivity Note This antibody is highly specific for basic FGF from bovine, human, rat, and mouse sources and does not cross-react with bovine acidic FGF (FGF-1, HBGF-1).

    Important Note: This antibody can cross-react with native and heat-inactivated basic FGF but will not neutralize biological activity (Uteza, Y., 1999). Upstate recommends anti-FGF-2/basic FGF, clone bFM-1 (neutralizing) (Catalog # 05-117) for neutralizing activity.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002006.3
    Entrez基因汇总 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
    基因符号
    • FGFB
    • FGF2
    • Prostatropin
    • BFGF
    • prostatropin
    • HBGF-2
    纯化方法 Ammonium sulfate precipitation and DEAE-cellulose chromatography
    UniProt编号
    • P09038
    UniProt汇总 FUNCTION: SwissProt: P09038 # The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.
    SIZE: 155 amino acids; 17254 Da
    SUBUNIT: Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.
    SIMILARITY: SwissProt: P09038 ## Belongs to the heparin-binding growth factors family.
    MISCELLANEOUS: This protein binds heparin more strongly than does aFGF.
    产品使用声明
    质量保证 Evaluated on basic FGF (Catalog #01-114).

    Western Blot Analysis:
    0.5-2 μg/mL of this antibody detected 100 ng FGF-2/basic FGF, carrier-free (Catalog # 01-114).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,05-118,Anti-FGF-2/basic FGF Antibody, clone bFM-2

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