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merck millipore,默克密理博,559270,Rb/Raf-1 Disruptor 251
产品名称：Rb/Raf-1 Disruptor 251
产品型号：559270
A cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction, while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/HDAC1, Raf-1/MEK1.
merck millipore,默克密理博,559270,Rb/Raf-1 Disruptor 251
- 产品介绍
重要规格表
经验配方 CAS号 C₈H₉Cl₃N₂S 72214-67-6 描述 概述 A cell-permeable and orally active isothiouronium compound that potently and selectively disrupts the Rb/Raf-1 interaction (IC50 = 77 nM in cell-free binding assays), while exhibiting no effect against Rb/B-Raf, Rb/E2F1, Rb/prohibitin, Rb/cyclin E, Rb/HDAC1, Raf-1/MEK1, or Raf-1/MEK2 interaction. Suppresses cellular E2F transcription activity and reduces serum-induced Rb phosphorylation. Shown to display Rb-dependent antitumor activity both in cultures in vitro and in mice in vivo. 产品目录编号 559270 品牌系列 Calbiochem®
同义词 S-(2,4-Dichlorobenzyl)-isothiouronium chloride, RRD-251 参考 参考 Kinkade, R., et al. 2008. Cancer Res. 68, 3810. 产品信息 CAS号 72214-67-6 形式 White solid Hill配方 C₈H₉Cl₃N₂S 化学配方 C₈H₉Cl₃N₂S Molar Mass 271.6 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. However, it is strongly recommended that stock solutions be prepared fresh just prior to each use. 包装信息 惰性气体下包装 Packaged under inert gas
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