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merck millipore,默克密理博,524619,PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem
产品名称：PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem
产品型号：524619
The PIP3 Antagonist II, DM-PIT-1, also referenced under CAS 701947-53-7, controls the biological activity of PIP3.
merck millipore,默克密理博,524619,PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₅N₃O₄S 701947-53-7 描述 概述 A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 (Cat. No. 524615) for binding PH domains of Akt1 (IC50 ≥31 µM), ARNO, GRP1, and PKD1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100 µM for 3 d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1 h 100 µM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-δ and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1 mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1 mg/kg micelles-formulated or 0.4 mg/kg free drug daily i.v., respectively). 产品目录编号 524619 品牌系列 Calbiochem®
同义词 N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide, N-((2-Hydroxy-5-nitrophenyl)carbamothioyl)-3,5-dimethylbenzamide, Akt Inhibitor XXII, PDK1 Inhibitor VI 参考 参考 Miao, B., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 20126.
Skidan, I., et al. 2009. Drug Deliv. 16, 45.产品信息 CAS号 701947-53-7 形式 Off-white powder Hill配方 C₁₆H₁₅N₃O₄S 化学配方 C₁₆H₁₅N₃O₄S Molar Mass 345.4 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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