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品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, M, R, Ht WB M Purified Monoclonal Antibody 描述 产品目录编号 04-638 商名 - Upstate
描述 Anti-TRF1 Antibody, clone BED5 57-6 Alternate Names - t-TRF1
- TERF1
- telomeric repeat binding factor (NIMA-interacting) 1
- FLJ41416
- PIN2
- TRBF1
- TRF
- TRF1
- hTRF1-AS
产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Affinity purified mouse ascites in PBS with 0.05% NaN3. 应用 应用 This Anti-TRF1 Antibody, clone BED5 57-6 is validated for use in WB, IF for the detection of TRF1. 主要应用 - Western Blotting
生物信息 免疫原品种 Human TRF1 protein 克隆 BED5 57-6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Detects TRF1 同种型 IgG1κ 品种反应性 MonkeyHumanMouseRatHamster 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_059523
Entrez基因汇总 This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq] 基因符号 - t-TRF1
- TERF1
- telomeric repeat binding factor (NIMA-interacting) 1
- FLJ41416
- PIN2
- TRBF1
- TRF
- TRF1
- hTRF1-AS
纯化方法 Protein G purfied UniProt编号 - P54274
UniProt汇总 FUNCTION: Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle.
SUBUNIT STRUCTURE: Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1.
SUBCELLULAR LOCATION: Nucleus. Spindle. Telomere. Note= Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.
TISSUE SPECIFICITY: Highly expressed and ubiquitous. Isoform Pin2 predominates.
INDUCTION:Pin2 expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis.
DOMAIN:The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.
PTM: Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.
SEQUENCE SIMILARITIES: Contains 1 HTH myb-type DNA-binding domain.产品使用声明 质量保证 Routinely evaluated by Western Blot on HeLa cell lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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