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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN240 Replaces AB5737 描述 Anti-Amyloid, β 1-40, aβ Antibody Alternate Names - Gamma-CTF(50)14.C31
- Amyloid beta A4 protein
- ABPP
- APPI
- APP
- Alzheimer disease amyloid protein
- Cerebral vascular amyloid peptide
- CVAP
- PreA4
- Protease nexin-II
- PN-II
- 1.N-APP2.Soluble APP-alpha
- S-APP-alpha3.Soluble APP-beta
- S-APP-beta4.C995.Beta-amyloid protein 42
- Beta-APP426.Beta-amyloid protein 40
- Beta-APP407.C838.P3(42)9.P3(40)10.C8011.Gamma-secretase C-terminal fragment 59
- Amyloid intracellular domain 59
- AICD-59
- AID(59)
- Gamma-CTF(59)12.Gamma-secretase C-terminal fragment 57
- Amyloid intracellular domain 57
- AICD-57
- AID(57)
- Gamma-CTF(57)13.Gamma-secretase C-terminal fragment 50
- Amyloid intracellular domain 50
- AICD-50
- AID(50)
背景信息 Amyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation. 产品信息 格式 Affinity Purified 控制 - Human Alzhiemer brain tissue lysate
演示 Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA. 主要应用 - ELISA
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer's diseased brain tissue.
ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct).生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40. 表位 P3(40) peptide 宿主 Rabbit 特异性 This antibody recognizes the P3(40) peptide of Amyloid, β 1-40. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, and Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001129601
基因符号 - AD1
- APP
- A4
纯化方法 Affinity purified UniProt编号 - P05067
产品使用声明 质量保证 Evaluated by Western Blot in human Alzheimer brain tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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