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描述 产品目录编号 14-614 品牌系列 Upstate
商名 - Upstate
描述 ALK4 Protein, active, 10 µg 概述 N-terminal GST-tagged, recombinant, human ALK4 amino acids 150-end. 应用 应用 Active, N-terminal GST-tagged, recombinant, human ALK4 amino acids 150-end. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Human ALK4 expressed by baculovirus in Sf21 insect cells. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_020328.2
- NM_004302.3
- NM_020327.2
Entrez基因汇总 Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. 基因符号 - ACTRIB
- ACVR1B
- ALK-4
- ACVRLK4
- ALK4
- SKR2
- ActRIB
- ACTR-IB
蛋白靶 ALK4 纯化方法 Glutathione-agarose 靶子系列 TKL UniProt编号 - P36896
UniProt汇总 FUNCTION: SwissProt: P36896 # On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
COFACTOR: Magnesium or manganese (By similarity).
SIZE: 505 amino acids; 56807 Da
SUBUNIT: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
SIMILARITY: SwissProt: P36896 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. & Contains 1 GS domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of casein. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C from date of shipment 包装信息 数量 10 µg
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