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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD133 描述 Anti-ACVR1B Antibody Alternate Names - SKR2
- Activin A receptor type IB
- Activin receptor-like kinase 4
- Activin receptor type 1B precursor
- ACTR-IB
- ACVRLK4
- ALK4
- ALK-4
- Serine/threonine-protein kinase receptor R2
背景信息 Activin receptor type-1B (ACVR1B) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. ACVR1B is known to form activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Within this receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors (including ACVR1B) act as downstream transducers of activin signals. Activins play role in many physiological and pathological processes including neuronal differentiation and neuronal survival, wound healing, extracellular matrix production, hair follicle development and cycling, FSH production, immunosuppression and carcinogenesis. ACVR1B is expressed highly in systemic sclerosis patient fibroblasts which suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. ACVR1B is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. 产品信息 格式 Affinity Purified 控制 - Human kidney tissue lysate
演示 Purified rabbit polyclonal PBS with up to 0.1% sodium azide. 应用 应用 Anti-ACVR1B Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human ACVR1B. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - ACVR1B
纯化方法 Antigen Affinity purified UniProt编号 - P36896
产品使用声明 质量保证 Evaluated by Western Blotting/Peptide Inhibition Assay in human kidney tissue lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected ACVR1B in 15 µg human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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