merck millipore,默克密理愽
  • merck millipore,默克密理博,ABN187,Anti-LRRK2 Antibody

  • merck millipore,默克密理博,ABN187,Anti-LRRK2 Antibody

    产品名称：Anti-LRRK2 Antibody
    产品型号：ABN187
    This Anti-LRRK2 Antibody is validated for use in WB, IH(P) for the detection of LRRK2. This antibody is known as JH5514 in scientific publications.

    merck millipore,默克密理博,ABN187,Anti-LRRK2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABN187,Anti-LRRK2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, MIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABN187
    描述 Anti-LRRK2 Antibody
    Alternate Names
    • JH5514
    • Leucine-rich repeat serine/threonine-protein kinase 2
    • Dardarin
    背景信息 LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2) is a multifunctional protein belonging to the ROCO family of proteins. LRRK2 contains multiple domains including a ROC (Ras of Complex protein) domain that binds and hydrolyzes GTP, and a kinase domain involved in the phosphorylation of myelin basic protein (MBP), mosein, ezrin, and radixin. LRRK2 itself undergoes autophosphorylation and is targeted by other kinases that modify multiple serine residues at its N-terminus; It is constitutively phosphorylated at Ser935 and maintains this state by interaction with the 14-3-3 protein. Although the kinases upstream of LRRK2 have not been definitively identified, previous studies have suggested that this group of kinases may include PKA. It also contains multiple leucine-rich repeat motifs that facilitate interaction with a range of proteins including PARK2 and PRDX3. Mutations in LRRK2, most of which have enhanced its kinase activity, may contribute to the development of late-onset familial Parkinson’s disease; however, the precise molecular mechanism of LRRK2-induced Parkinson’s disease is still unclear.
    产品信息
    格式 Affinity Purified
    控制
    • Mouse brain tissue lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-LRRK2 Antibody is validated for use in WB, IH(P) for the detection of LRRK2. This antibody is known as JH5514 in scientific publications.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western Blot Analysis: A representative lot was used by an independent laboratory in HEK-293T cells transiently transfected with myc-tagged WT or mutant LRRK2. (West, A., et al. (2005). PNAS. 102(46):16842–16847.)

    Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in neurons from mouse forebrain tissue. (Higashi, S., et al. (2007). Journal of Neurochemistry. 100:368–381.)

    Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in transfected HEK-293T cells. (West, A., et al. (2005). PNAS. 102(46):16842–16847.)

    Immunofluorescence Analysis: A representative lot was used by an independent laboratory in transfected HEK-293T cells. (West, A., et al. (2005). PNAS. 102(46):16842–16847.)
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human LRRK2.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 HumanMouse
    Species Reactivity Note Demonstrated to react with Mouse and Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_940980
    基因符号
    • PARK8
    • LRRK2
    纯化方法 Affinity purified
    UniProt编号
    • Q5S007
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse brain tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected LRRK2 in 10 µg of mouse brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABN187,Anti-LRRK2 Antibody

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