merck millipore,默克密理博,AB10512,Anti-Caspase 6 (active form) Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
Chp, R, H, B, Fe	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB10512
Replaces	04-1045
描述	Anti-Caspase 6 (active form) Antibody
Alternate Names	caspase 6, apoptosis-related cysteine protease Apoptotic protease Mch-2 caspase 6 caspase 6, apoptosis-related cysteine peptidase
背景信息	Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase 6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two subunits, an 18 kDa and a 10 kDa subunit that dimerize to form the active enzyme (3). Caspase 6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).

产品信息
格式	Affinity Purified
控制	Rat kidney tissue lysate
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

应用
应用	Detect Caspase 6 (active form) using this Anti-Caspase 6 (active form) Antibody validated for use in WB, IH.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected Caspase 6 in colorectal carcinoma tissue.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the C-terminus of the large subunit of rat Caspase 6.
表位	C-terminus of the large subunit of Caspase 6
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	The antibody recognizes the large subunit of active Caspase 6.
品种反应性	ChimpanzeeRatHumanBovineFeline
Species Reactivity Note	Demonstrated to react with human and rat. Predicted to react with bovine, feline, and chimpanzee based on 100% sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_113963
Entrez基因汇总	Member of the cysteine-aspartic acid protease (caspase) family that plays a terminal role in apoptosis [RGD].
基因符号	MCH2 CASP-6
纯化方法	Affinity Purfied
UniProt编号	Q6AZ23
UniProt汇总	SEQUENCE SIMILARITIES: Belongs to the peptidase C14A family.

产品使用声明
质量保证	Evaluated by Western Blot in rat kidney tissue lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Caspase 6 in 10 µg of rat kidney tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,AB10512,Anti-Caspase 6 (active form) Antibody

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