merck millipore,默克密理博,MABC186,Anti-phospho-p62/SQSTM1 (Ser403) Antibody, clone 4F6

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	R	Purified	Monoclonal Antibody

描述
产品目录编号	MABC186
描述	Anti-phospho-p62/SQSTM1 (Ser403) Antibody, clone 4F6
Alternate Names	Ubiquitin-binding protein p62 Sequestosome-1 EBI3-associated protein of 60 kDa EBIAP p60 Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
背景信息	Ubiquitin-binding protein p62, also known as Sequestosome-1 (SQSTM1), is a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-κB in response to upstream signals. Defects in p62/SQSTM1 are a cause of Paget disease of bone (PDB), a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts.

产品信息
格式	Purified
控制	miR-P62 cell lysate
演示	Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect the phospho-p62/SQSTM1 (Ser403) protein using this Anti-phospho-p62/SQSTM1 (Ser403), clone 4F6 validated for use in WB & IHC.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A representative lot was used by an an independent laboratory to detect p62/SQSTM1 (Ser403) in Atg5 conditional knockout mouse brain tissue. (Matsumoto, G., et al. (2011). Molecular Cell. 44:279-289). Western Blot Analysis: A representative lot was used by an an independent laboratory to detect p62/SQSTM1 (Ser403) in Atg5 expressing and Atg5 conditional knockout G-p62 cell lysates that were treated with either BafA or OA. (Matsumoto, G., et al. (2011). Molecular Cell. 44:279-289).

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human phospho p62/SQSTM1 (Ser403).
表位	phosphorylated at Ser403
克隆	4f6
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rat
特异性	This antibody recognizes p62/SQSTM1 phosphorylated at Ser403.
同种型	IgG2aκ
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human and Mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001135770
基因符号	OSIL SQSTM1 ORCA
纯化方法	Protein G purified
UniProt编号	Q13501

产品使用声明
质量保证	Evaluated by Western Blot in miR-P62 cell lysate. Western Blot Analysis: 1.0 µg/mL of this antibody detected p62/SQSTM1 (Ser403) in 10 µg of MG132 treated miR-P62 and miR-P62 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABC186,Anti-phospho-p62/SQSTM1 (Ser403) Antibody, clone 4F6

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