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merck millipore,默克密理博,ABE57,Anti-LMX-1.2 Antibody
产品名称：Anti-LMX-1.2 Antibody
产品型号：ABE57
Anti-LMX-1.2 Antibody is a Rabbit Polyclonal Antibody for detection of LMX-1.2 also known as LIM homeobox transcription factor 1 beta1, LIM/homeobox protein LMX1B & has been validated in WB & IHC.
merck millipore,默克密理博,ABE57,Anti-LMX-1.2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE57 描述 Anti-LMX-1.2 Antibody Alternate Names - LIM homeobox transcription factor 1-beta
- LIM homeobox transcription factor 1, beta1
- LIM/homeobox protein LMX1B
- LIM/homeobox protein 1.2
背景信息 LIM/homeobox protein 1.2 (LMX-1.2) belongs to the LIM homeodomain protein family and is comprised of 2 LIM zinc-binding domains and a single homeobox DNA-binding domain. LMX-1.2 is a required for determination of dorsal limb fate at the autopodal and zeugopodal levels during development, and is necessary for the normal development of eye, kidney, and skull. Expression is reported in the majority of tissues, with highest observed levels found in duodenum, pancreatic islets, skeletal muscle, testis, and thyroid. It is observed in the CNS, specifically is the isthmus, developing dopenergic and serotonergic neurons within the midgrain and hindbrain, roof and floor plate of the neural tube, and in a small group of dorsal spinal chord interneurons. Defects in expression causes nail-patella syndrome (NPS) which results in renal dysplasia and aberrant skeletal patterning. 产品信息 格式 Serum 控制 - Human fetal skeletal muscle tissue lysate
演示 Rabbit polyclonal serum containing 0.5% sodium azide. 应用 应用 Anti-LMX-1.2 Antibody is a Rabbit Polyclonal Antibody for detection of LMX-1.2 also known as LIM homeobox transcription factor 1 beta1, LIM/homeobox protein LMX1B & has been validated in WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Dreyer, S. D., et al. (2000). Human Molecular Genetics. 9(7):1067-1074). 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human LMX-1.2. 宿主 Rabbit 同种型 IgG 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002307
Entrez基因汇总 This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 基因符号 - NPS1
- LMX1B
- LMX1.2
- LMX-1.2
纯化方法 Unpurified UniProt编号 - O60663
UniProt汇总 FUNCTION: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
SUBCELLULAR LOCATION: Nucleus Potential.
TISSUE SPECIFICTY: Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets.
INVOLVEMENT IN DISEASE: Defects in LMX1B are the cause of nail-patella syndrome (NPS) [MIM:161200]; also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia.
SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.
SEQUENCE CAUTION: The sequence CAH70294.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI40917.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1.2 on 10 µg of human fetal skeletal muscle tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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