merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL453P,Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated

  • merck millipore,默克密理博,CBL453P,Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated

    产品名称：Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated
    产品型号：CBL453P
    Detect CD14 using this Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated validated for use in FC.

    merck millipore,默克密理博,CBL453P,Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL453P,Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, HFCMPhycoerythrinMonoclonal Antibody
    描述
    产品目录编号 CBL453P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated
    Alternate Names
    • LPS Receptor
    产品信息
    格式 Phycoerythrin
    演示 The conjugate is supplied as a 100 test/1 mL vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
    应用
    应用 Detect CD14 using this Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated validated for use in FC.
    主要应用
    • Flow Cytometry
    应用说明 Identification of monocytic cells by direct immunofluorescence staining on frozen sections or flow cytometry

    Identification of cells of monocyte lineage by immunohistological staining of tissue sections

    Study of follicular architecture in lymphoid tissue with malignant involvement

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human thymocytes and peripheral blood mononuclear cells from an AML patient
    克隆 UCHM-1
    宿主 Mouse
    特异性 The antibody detects a 55 kDa GPI-linked glycoprotein structure predominantly on monocytes, macrophages and less strongly on granulocytes. Monocytic cells, interfollicular dendritic cells and dendritic reticulum cells are stained in sections of lymphoid tissue. The CD14 molecule is comprised of 365 amino acids and is anchored to the plasma membrane via a cleavable phosphoinositol linkage. CD14 is the LPS and LPS-binding protein receptor.

    Antigen distribution:

    Monocytes > 98%

    Granulocytes > 60%

    LGL cells < 5%

    Peripheral blood lymphocytes < 1%

    T cells (CD3+) < 1%

    B cells (CD20+) < 1%

    Thymocytes < 1%

    KNOWN SPECIES CROSS REACTIVITY: This antibody is positive on rhesus monkey PBLs in flow cytometry

    FUSION PARTNER: SP2/0
    同种型 IgG2a
    品种反应性 MonkeyHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001040021.1
    • NM_000591.2
    Entrez基因汇总 CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Alternative splicing results in multiple transcript variants encoding the same isoform.
    基因符号
    • CD14
    UniProt编号
    • P08571
    UniProt汇总 FUNCTION: SwissProt: P08571 # Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
    SIZE: 375 amino acids; 40076 Da
    SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.
    SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
    TISSUE SPECIFICITY: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
    SIMILARITY: SwissProt: P08571 ## Contains 11 LRR (leucine-rich) repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL453P,Anti-CD14 Antibody, clone UCHM-1, Phycoerythrin conjugated

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