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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB Rb Unpurified Polyclonal Antibody 描述 产品目录编号 07-1392 描述 Anti-Rab40C Antibody Alternate Names - SOCS box-containing protein RAR3
- RAB40C, member RAS oncogene family
- RAR (RAS like GTPASE) like
- RAR like
- RAS-like GTPase
- RAS-like, family 8, member C
- Rar-like protein
- Ras-like protein family member 8C
- member C
- Rar-like protein
- Ras-like protein family member 8C
背景信息 The Rab family of proteins are a member of the Ras superfamily of small G-Proteins. At least 60 isoforms have been identified. These GTPases are primarily involved in regulating distinct steps in vesicle trafficking by regulating the dynamic assembly and disassembly of the multi-protein scaffolds that are involved in vesicle trafficking. In its active, GTP-bound state, the Rab protein recruits effector proteins to the membrane. Rabs lack intrinsic GTPase hydrolysis activity and thus rely on guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) to regulate their activity. Through these effectors, they regulate vessicle formation and movement. Rab4 and Rab11 are involved in internalization, sorting and transport to lysosomes or recycling of several membrane proteins, including GPCRs, GLUT-4, Aquaporin-2 or the H+/K+ ATPase. 产品信息 格式 Unpurified 演示 Rabbit Serum 应用 应用 Use Anti-Rab40C Antibody (Rabbit Polyclonal Antibody) validated in WB, IHC to detect Rab40C also known as RAS-like GTPase, SOCS box-containing protein RAR3. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blot Analysis :
Immunohistochemistry Analysis:
Immunohistochemistry (IHC) staining of mouse epithelium cells during lung development. Antibody was used at a 1:1,000 dilution and stained overnight at 4°C. 10X amplification.
生物信息 免疫原品种 Full-length His-tagged Rab40C recombinant protein (mouse). 宿主 Rabbit 特异性 Detects Rab40C 品种反应性 RatHumanMouse Species Reactivity Note Human, Mouse, and Rat. Other species have not been tested. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_066991
基因符号 - RAB40C
- RARL
- RASL8C
纯化方法 Unpurified UniProt编号 - Q96S21
UniProt汇总 Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and RAB40C. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic sidePotential.
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes By similarity.
Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
Contains 1 SOCS box domain产品使用声明 质量保证 Western Blot Analysis:
This lot detected Rab40C at 1:1,000 dilution in Rat lung lysate resolved via SDS-PAGE and transferred to PVDF
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt. Store at -80°C for longer term storage. Avoid repeated freeze/thaws.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
包装信息 数量 100 µL
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