- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,ABE236,Anti-CDK5RAP2 Antibody
产品名称：Anti-CDK5RAP2 Antibody
产品型号：ABE236
Anti-CDK5RAP2 Antibody is a Rabbit Polyclonal Antibody for detection of CDK5RAP2 also known as CDK5 activator-binding protein C48 & has been validated in WB, ICC & IHC.
merck millipore,默克密理博,ABE236,Anti-CDK5RAP2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H IHC, WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE236 描述 Anti-CDK5RAP2 Antibody Alternate Names - CDK5 activator-binding protein C48
- CDK5 regulatory subunit-associated protein 2
背景信息 CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly. 产品信息 格式 Affinity Purified 控制 - NIH/3T3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-CDK5RAP2 Antibody is a Rabbit Polyclonal Antibody for detection of CDK5RAP2 also known as CDK5 activator-binding protein C48 & has been validated in WB, ICC & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected CDK5RAP2 in NIH/3T3 and A431 cells.
Immunohistochemistry Analysis: This antibody was used by an independent laboratory in IHC (see 2. Barrera, J.A., et al. (2010). Dev Cell. 18(6):913-926.)生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the N-terminus of mouse CDK5RAP2. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes CDK5RAP2 at the N-terminus. 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with Mouse, Human, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_666102
基因符号 - Cdk5rap2
纯化方法 Affinity purified UniProt编号 - Q8K389
UniProt汇总 FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Involved in regulation of mitotic spindle orientation By similarity. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation and brain development.
SUBUNIT STRUCTURE: Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 (By similarity). Interacts with PCNT; the interaction is leading to centrosomal localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9 (By similarity). Interacts with TUBG1; the interaction is leading to centrosomal localization of CDK5RAP2 and TUBG1. Interacts with TUBGCP3 (By similarity). Interacts with CALM1 (By similarity). Interacts with CDC20 (By similarity). According to Ref.4, CDK5RAP2 does not interact with MAPRE1.
SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton › centrosome. Golgi apparatus (By similarity). Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in testis, thymus, heart and brain. Ref.6
DEVELOPMENTAL STAGE: Expressed from E9.5 in the developing cortex. Its expression peaks during periods of active neurogenesis.
PTM: Phosphorylated in vitro by CDK5 (By similarity).
SEQUENCE CAUTION: The sequence BAC98221.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.产品使用声明 质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected CDK5RAP2 on 10 µg of NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,ABN652,Anti-VGF Antibody
下一件merck millipore产品：merck millipore,默克密理博,04-1460,Anti-PRMT5 Antibody, clone 23C7
相关产品
merck millipore,默克密理博,17-10227,LentiBrite ™ PSD95-GFP Lentiviral Biosensor
merck millipore,默克密理博,AB5840,Anti-Dab1 Antibody
merck millipore,默克密理博,MAB4314X,Anti-CD93 Antibody, clone R139, Alexa Fluor 488 conjugated
merck millipore,默克密理博,MAB1973,Anti-Integrin α1 Antibody, clone FB12
merck millipore,默克密理博,ABN652,Anti-VGF Antibody
merck millipore,默克密理博,04-1460,Anti-PRMT5 Antibody, clone 23C7
merck millipore,默克密理博,07-685,Anti-Lactotransferrin Antibody
merck millipore,默克密理博,MSHVN4550,MultiScreenHTS HV，0.45 µm，无色，非无菌
merck millipore,默克密理博,672081,Urokinase, High Molecular Weight, Human Urine
merck millipore,默克密理博,07-2191,Anti-phospho-CapZIP Antibody (Ser179)