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品种反应性 主要应用 宿主 格式 抗体类型 Ox, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-2191 描述 Anti-phospho-CapZIP Antibody (Ser179) Alternate Names - RCSD domain-containing protein 1
- RCSD domain containing 1
- capZ-interacting protein
- Protein kinase substrate CapZIP
- protein kinase substrate MK2S4
背景信息 CapZIP (CapZ-interacting protein) is highly expressed in immune cells and muscle and uniquely interacts with CapZ, an F-actin capping protein, in splenocytes. Phosphorylation of CapZIP is thought to regulate CapZ ability to remodel actin filament assembly. CapZIP may also contain a CPI (capping protein interaction) motif that seems to restrict capping protein to a low-affinity, filament-binding conformation. 产品信息 格式 Affinity Purified 控制 - Lambda phosphatase treated and untreated Jurkat plus Sorbitol cell lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This phospho-CAPZIP antibody is validated for use in WB for the detection of the phospho-CAPZIP protein. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human CapZIP phosphorylated at Ser179. 表位 Phosphorylated Ser179 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes CapZIP when phosphorylated at Ser179. 品种反应性 OxHuman Species Reactivity Note Demonstrated to react with human. Predicted to react with ox based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_443094
基因符号 - RCSD1
- CAPZIP
- MK2S4
修改 - Phosphorylation
纯化方法 Affinity purified UniProt编号 - Q6JBY9
UniProt汇总 FUNCTION: Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.
SUBUNIT STRUCTURE: Interacts with CAPZA2 and CAPZB.
TISSUE SPECIFICITY: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.
POST-TRANSLATIONAL MODIFICATION: Dephosphorylation results in its dissociation from CAPZA2.
SEQUENCE SIMILARITIES: Contains 1 RCSD domain.
SEQUENCE CAUTION: The sequence CAB70910.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in lambda phosphatase treated and untreated Jurkat plus Sorbitol cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected CapZIP on 10 µg of lambda phosphatase treated and untreated Jurkat plus Sorbitol cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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