merck millipore,默克密理愽
  • merck millipore,默克密理博,ABE136,Anti-NFκB p65 Antibody

  • merck millipore,默克密理博,ABE136,Anti-NFκB p65 Antibody

    产品名称：Anti-NFκB p65 Antibody
    产品型号：ABE136
    Anti-NFκB p65 Antibody is a Rabbit Polyclonal Antibody for detection of NFκB p65 also known as v-rel reticuloendotheliosis viral oncogene homolog A & has been validated in WB & IP.

    merck millipore,默克密理博,ABE136,Anti-NFκB p65 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE136,Anti-NFκB p65 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE136
    描述 Anti-NFκB p65 Antibody
    Alternate Names
    • v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65))
    • v-rel reticuloendotheliosis viral oncogene homolog A (avian)
    • v-rel reticuloendotheliosis viral oncogene homolog A
    • v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa<br />light polypeptide gene enhancer in B-cells 3, p65
    • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
    • Nuclear factor NF-kappa-B p65 subunit
    背景信息 The transcription factor NFkappaB (Nuclear Factor kappaB) is involved in the expression and regulation of a number of important cellular and physiological processes such as growth, development, apoptosis, immune and inflammatory response, and activation of various viral promoters including human immunodeficiency virus long terminal repeats. NFkappaB represents a group of structurally related and evolutionarily conserved proteins related to the proto-oncogene c-Rel with five members in mammals that include Rel (cRel), RelA (p65), RelB, NFkappaB1 (p50 and its precursor p105), and NFkappaB2 (p52 and its precursor p100). NFkappaB/Rel proteins exist as homo- or heterodimers to form transcriptionally competent or repressive complexes. Although most NFkappaB dimers are activators of transcription, the p50/50 and p52/52 homodimers can repress the transcription of their target genes. The p50/p65 heterodimer of NFkappaB is the most abundant in cells.
    产品信息
    格式 Affinity Purified
    控制
    • A431 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-NFκB p65 Antibody is a Rabbit Polyclonal Antibody for detection of NFκB p65 also known as v-rel reticuloendotheliosis viral oncogene homolog A & has been validated in WB & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: 10 µg of a representative lot of antibody has been shown to immunoprecipitate NFκB p65 from A431 RIPA lysate.

    Western Blot (SNAP ID) Analysis: 1:250 dilution of representative lot of this antibody has been shown to detect NFκB p65 on 10 µg of A431 cell lysate.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human NFκB p65.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the C-terminus of NFκB p65.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_068810
    Entrez基因汇总 NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or
    5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM].
    基因符号
    • p65
    • RELA
    • NFKB3
    纯化方法 Affinity Purfied
    UniProt编号
    • Q04206
    UniProt汇总 FUNCTION: p65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF- kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.

    SIZE: 551 amino acids; 60219 Da

    SUBUNIT: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer. May interact with ETHE1. Binds AES and TLE1. Interacts with TP53BP2. Binds to and is phosphorylated by the activated form of either RPS6KA4 or RPS6KA5. Interacts with ING4 and this interaction may be indirect. Interacts with CARM1, USP48 and UNC5CL.

    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).

    PTM: Ubiquitinated, leading to its proteosomal degradation. Degradation is required for termination of NF-kappa-B response.

    SIMILARITY: Contains 1 RHD (Rel-like) domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in A431 cell lysate.

    Western Blot Analysis: 1:2,500 dilution of this antibody detected NFκB p65 on 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,ABE136,Anti-NFκB p65 Antibody

上一件merck millipore产品：merck millipore,默克密理博,SF-998,Dot1L; Mouse, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,PP54-KSP,Mouse IgG, (Purified From Serum (1mg)


相关产品

merck millipore,默克密理博,15-119,Cell Cycle-S Phase Pathway Explorer Antibody MiniPack merck millipore,默克密理博,15-119,Cell Cycle-S Phase Pathway Explorer Antibody MiniPack

merck millipore,默克密理博,71753,LB Broth, Miller - Novagen merck millipore,默克密理博,71753,LB Broth, Miller - Novagen

merck millipore,默克密理博,AB15102,Anti-Mint-1 Antibody merck millipore,默克密理博,AB15102,Anti-Mint-1 Antibody

merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

merck millipore,默克密理博,SF-998,Dot1L; Mouse, Cyanine 5 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-998,Dot1L; Mouse, Cyanine 5 RNA Detection Probe,SmartFlare

merck millipore,默克密理博,PP54-KSP,Mouse IgG, (Purified From Serum (1mg) merck millipore,默克密理博,PP54-KSP,Mouse IgG, (Purified From Serum (1mg)

merck millipore,默克密理博,539834,Prostate Specific Antigen, Enzymatically Active, Human Seminal Fluid merck millipore,默克密理博,539834,Prostate Specific Antigen, Enzymatically Active, Human Seminal Fluid

merck millipore,默克密理博,FCIM025161,FlowCellect™ Mouse Th1 Differentiation Tool Kit merck millipore,默克密理博,FCIM025161,FlowCellect™ Mouse Th1 Differentiation Tool Kit

merck millipore,默克密理博,MAB3507,Anti-Caspase 2 Antibody, clone 11B4 merck millipore,默克密理博,MAB3507,Anti-Caspase 2 Antibody, clone 11B4

merck millipore,默克密理博,UFC801096,Amicon Ultra-4，PLGC Ultracel-PL 超滤膜，10 kDa merck millipore,默克密理博,UFC801096,Amicon Ultra-4，PLGC Ultracel-PL 超滤膜，10 kDa


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部