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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15102 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Mint-1 Antibody 产品信息 格式 Serum 演示 Liquid 应用 应用 Detect Mint-1 using this Anti-Mint-1 Antibody validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:5,000-1:10,000 using ECL (5 min exposure)
Optimal working dilutions must be determined by the end user.
生物信息 免疫原品种 Synthetic peptide from rat. 宿主 Rabbit 特异性 Mint-1. By Western blot the antibody recognizes a band at ~130 kDa in rat brain lysate. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001163.2
Entrez基因汇总 The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. 基因符号 - MINT1
- APBA1
- D9S411E
- X11
- X11A
- X11ALPHA
纯化方法 Serum UniProt编号 - Q02410
UniProt汇总 FUNCTION: SwissProt: Q02410 # Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
SIZE: 837 amino acids; 92865 Da
SUBUNIT: Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).
TISSUE SPECIFICITY: Brain and spinal cord.
DOMAIN: SwissProt: Q02410 Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
SIMILARITY: Contains 2 PDZ (DHR) domains. & Contains 1 PID domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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