merck millipore,默克密理愽
  • merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

  • merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

    产品名称：Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem
    产品型号：553509
    A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II compl More>>

    merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₂₀N₄O₃171927-40-5
    描述
    概述 A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
    产品目录编号 553509
    品牌系列 Calbiochem®
    同义词 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
    参考
    参考 Huber, K. V. M., et al. 2014. Nature In press.
    He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
    Walsh, A.B., et al. 1997. Oncogene 15, 2553.
    Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
    产品信息
    CAS号 171927-40-5
    具有ATP竞争性 N
    形式 Light-yellow solid
    Hill配方 C₁₆H₂₀N₄O₃
    化学配方 C₁₆H₂₀N₄O₃
    Molar Mass 316.4
    可逆 N
    结构配方图像
    生物信息
    主靶 Ras/Rac
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553509,Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

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