- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC83 描述 Anti-Angptl3 Antibody Alternate Names - Angiopoietin-like protein 3
- Angiopoietin-related protein 3
背景信息 The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-Terminal coiled coil domain and the C terminal Fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha 5 beta 3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. Angptl3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-rich HDL particles have high cholesterol efflux abilities. Defects in Angptl3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2) also called combined hypobetalipoproteinemia familial. 产品信息 格式 Affinity Purified 控制 - HepG2 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Angptl3 using this Anti-Angptl3 Antibody validated for use in Western Blotting, Immunofluorescence, IHC(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:100-500 dilution from a representative lot detected Angptl3 in human liver, human cardiac myocytes, mouse liver, rat liver, and rat kidney tissues. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the coiled coil region of mouse Angptl3. 宿主 Rabbit 特异性 This antibody recognizes the coiled coil region of Angptl3. 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_038941
基因符号 - Angptl3
纯化方法 Affinity purified UniProt编号 - Q9R182
产品使用声明 质量保证 Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Angptl3 in 10 µg of HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,SF-1298,GDF3; Human, Cyanine 3 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,AG400,BLACK-GOLD II Stain
相关产品
merck millipore,默克密理博,427217,Lactate Dehydrogenase, Rabbit Muscle
merck millipore,默克密理博,07-1233,Anti-Notch 2 Antibody, intracellular
merck millipore,默克密理博,MAB4130,Anti-Thymidylate Synthase Antibody, clone TS106
merck millipore,默克密理博,SF-1298,GDF3; Human, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,AG400,BLACK-GOLD II Stain
merck millipore,默克密理博,07-791,Anti-phospho-Src Antibody (Tyr215)
merck millipore,默克密理博,ABC826,Anti-BCAS3 Antibody
