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merck millipore,默克密理博,MABN46,Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1
产品名称：Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1
产品型号：MABN46
Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1 detects level of Chloride intracellular channel protein (CLIC1) & has been published & validated for use in WB, IH.
merck millipore,默克密理博,MABN46,Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1
- 产品介绍
- merck millipore,默克密理博,MABN46,Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN46 描述 Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1 Alternate Names - chloride intracellular channel protein 1
- chloride intracellular channel 1
- Chloride channel ABP
- RNCC protein
- Nuclear chloride ion channel 27
- nuclear chloride ion channel protein
- Regulatory nuclear chloride ion channel protein
背景信息 Chloride intracellular channel protein 1 (CLIC1) is a part of the CLIC family of proteins. This family of proteins reconstitute in phospholipid vesicles and have been shown to have chloride channel action. CLIC1 may rotate between membrane-bound and soluble forms since it has been seen as a membrane protein and in the cytoplasm. When there is a lack of detergent, CLIC1 becomes membrane-bound and can act as an anion-selective channel. Recently, it has been shown that CLIC1 is required in angiogenesis and has a part in controlling integrin cell surface expression. 产品信息 格式 Purified 控制 - Human liver tissue lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1 detects level of Chloride intracellular channel protein (CLIC1) & has been published & validated for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. 生物信息 免疫原品种 Full length recombinant protein corresponding to human CLIC1.
Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.克隆 CPTC-CLIC1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001279
Entrez基因汇总 Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq]. 基因符号 - hRNCC
- CLIC1
- G6
- NCC27
- p64CLCP
纯化方法 Protein G UniProt编号 - O00299
UniProt汇总 FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
SUBUNIT STRUCTURE: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9.
SUBCELLULAR LOCATION: Nucleus. Nucleus membrane; Single-pass membrane protein Probable. Cytoplasm. Cell membrane; Single-pass membrane protein Probable. Note: Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
TISSUE SPECIFICTY: Expression is prominent in heart, placenta, liver, kidney and pancreas.
DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
PTM: Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
MISCELLANEOUS: The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals.
SEQUENCE SIMILARITIES: Belongs to the chloride channel CLIC family.
Contains 1 GST C-terminal domain.产品使用声明 质量保证 Evaluated by Western Blot in human liver tissue lysate.
Western Blot Analysis: 0.25 µg/mL of this antibody detected CLIC1 on 10 µg of human liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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