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品种反应性 主要应用 宿主 格式 抗体类型 H, M IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC402 描述 Anti-ANGPTL2 Antibody Alternate Names - ANGPTL2
- Angiopoietin-related protein 2
- Angiopoietin-like protein 2
背景信息 The protein named Angiopoietin-related protein 2 (ANGPTL2) or Angiopoietin-like protein 2 and encoded by the human gene named ANGPTL2/ARP2 is a secreted protein that is highly expressed in several tissues including the heart, spleen, stomach, colon, ovary and skeletal muscle. ANGPTL2 functions to induce endothelial cell sprouting in preparation for angiogenesis. ANGPTL2 is produced by endothelial cells and ANGPTL2 appears to function as an autocrine in helping to promote the sprouting response. ANGPTL2 also appears to use the same autocrine function in certain cancers and in particular in driving of metastasis. Recent research have demonstrated that tumor cell–derived ANGPTL2 increased in vitro motility and invasion in an autocrine/paracrine manner, conferring an aggressive metastatic tumor phenotype on the cells examined. Thus research is now focused on blocking the function of ANGPTL2 as one possible treatment for metastatic cancers. EMD-Millipore’s Anti-ANGPTL2 rabbit polyclonal antibody has been tested in western blot on mouse small intestine tissue extracts and in paraffin embedded immunohistochemistry on human heart tissue sections. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol. 应用 应用 Anti-ANGPTL2 Antibody is a highly specific rabbit polyclonal antibody, that targets ANGPTL & has been tested in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ANGPTL2 in human heart tissue. 生物信息 免疫原品种 GST-tagged fusion protein corresponding to human ANGPTL2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 HumanMouse 抗体类型 Polyclonal Antibody 基因符号 - ARP2
- ANGPTL2
纯化方法 Antigen Affinity purified UniProt编号 - Q9UKU9
产品使用声明 质量保证 Evaluated by Western Blotting in mouse small intestine tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ANGPTL2 in mouse small intestine tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.包装信息 数量 150 µL
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