merck millipore,默克密理博,MAB2015,Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4

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merck millipore,默克密理博,MAB2015,Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4
产品名称：Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4
产品型号：MAB2015
Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4 detects level of Cartilage Proteoglycan & has been published & validated for use in ELISA, RIA, WB, IH.

merck millipore,默克密理博,MAB2015,Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4

产品介绍

merck millipore,默克密理博,MAB2015,Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Sh, B, Ca, Ch, H, Po, Rb	IHC, ELISA, WB	M	Ascites	Monoclonal Antibody

描述
产品目录编号	MAB2015
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4

产品信息
格式	Ascites
演示	Ascites fluid

应用
应用	Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4 detects level of Cartilage Proteoglycan & has been published & validated for use in ELISA, RIA, WB, IH.
主要应用	Immunohistochemistry ELISA Western Blotting
应用说明	Western blot: 1:1,00 - 1:200 Immunohistochemistry: 1:50 - 250 ELISA: 1:250 - 1: 2500 RIA: 1:20,000 - 1:40,000 Optimal working dilutions must be determined by the end user.I/

生物信息
免疫原品种	Human adult cartilage proteoglycan.
表位	adult
克隆	EFG-4
宿主	Mouse
特异性	Recognizes the short peptides substituted with keratan sulfate side chains and within the core protein of proteoglycans in articular cartilages, chicken limb bud and cornea. Does not cross-react with human fetal cartilage proteoglycans.
同种型	IgG1κ
品种反应性	SheepBovineCanineChickenHumanPigRabbit
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_013227.2 NM_001135.2
Entrez基因汇总	This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
基因符号	CSPGCP ACAN MSK16 SEDK CSPCP AGCAN AGC1 CSPG1
非反应性品种	Rat Mouse
UniProt编号	P16112
UniProt汇总	FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. SIZE: 2415 amino acids; 250193 Da SUBUNIT: Interacts with FBLN1 (By similarity). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). TISSUE SPECIFICITY: Restricted to cartilages. DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton. DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3. PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

包装信息
数量	100 µL

merck millipore,默克密理博,MAB2015,Anti-Cartilage Proteoglycan Antibody, adult, clone EFG-4

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