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merck millipore,默克密理博,580566,Tenovin-1 - CAS 380315-80-0 - Calbiochem
产品名称：Tenovin-1 - CAS 380315-80-0 - Calbiochem
产品型号：580566
A cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC₅₀ = ~ 10 µM).
merck millipore,默克密理博,580566,Tenovin-1 - CAS 380315-80-0 - Calbiochem
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经验配方 CAS号 C₂₀H₂₃N₃O₂S 380315-80-0 描述 概述 A cell-permeable benzoylthiourea compound that acts as a reversible inhibitor of class III HDAC sirtuins against SirT2 (IC50 = ~ 10 µM). Based on studies using the more soluble analog Tenovin-6, Tenovin-1 is expected not to compete with substrate binding and display lower potency against SirT1/3 (IC50 = 21/67 µM using Tenovin-6). Tenovin-1 (10 µM) up-regulates cellular p53 protein, but not mRNA, level in MCF-7 (≥6-fold in 6 h), presumably by blocking mdm2-mediated p53 degradation. Two day Tenovin-1 treatment (10 µM) results in selective killing of cancer cells with functional p53, but not p53-lacking cancer cells or normal human dermal fibroblasts. Despite its low aqueous solubility, administration of Tenovin-1 suspension is shown to effectively reduce BL2 and ARN8 xenographs in mice in vivo (≥50% reduction with 92 mg/kg, daily, i.p.). 产品目录编号 580566 品牌系列 Calbiochem®
同义词 N-(4-tert-Butylbenzoyl)-Nʹ-(4-acetylaminophenyl)-thiourea, SIRT2 Inhibitor V 参考 参考 Lain, S., et al. 2008. Cancer Cell 13, 454. 产品信息 CAS号 380315-80-0 形式 White solid Hill配方 C₂₀H₂₃N₃O₂S 化学配方 C₂₀H₂₃N₃O₂S Molar Mass 369.5 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 安全信息 S相 S: 22-24/25-36-45
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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