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经验配方 CAS号 C₁₅H₁₆ClN₅ 172889-27-9 描述 概述 A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available. 产品目录编号 529573 品牌系列 Calbiochem®
同义词 AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 参考 参考 Karni, R., et al. 2003. FEBS Lett. 537, 47.
Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371.
Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.
产品信息 CAS号 172889-27-9 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₁₅H₁₆ClN₅ 化学配方 C₁₅H₁₆ClN₅ Molar Mass 301.8 可逆 Y 结构配方图像 生物信息 主靶 p56lck 主靶IC50 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck, and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C. 包装信息 惰性气体下包装 Packaged under inert gas
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