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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9374 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-LR11 Antibody Alternate Names - low-density lipoprotein receptor relative with 11 binding repeats
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl with 0.1% sodium azide. 应用 应用 Anti-LR11 Antibody is an antibody against LR11 for use in WB. 主要应用 - Western Blotting
应用说明 Immunoblotting: 0.5-1.0 μg/mL on HEK cells transfected with LR11. The antibody reacts with the ~250 kD LR11 protein.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from human LR11. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes LR11 [low-density lipoprotein receptor relative with 11 binding repeats]. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003105.3
Entrez基因汇总 This gene encodes a protein that belongs to the families of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins, of low density lipoprotein receptor (LDLR) proteins, and of fibronectin type III repeats proteins. In addition to VPS10, LDLR and fibronectin type 3 domains, this protein also includes an epidermal growth factor precursor-like module, a single transmembrane segment and a cytoplasmic tail with features similar to endocytosis- and sorting-competent receptors. Members of the VPS10 domain-containing receptor family are large with many exons but the CDS lengths are usually less than 3700 nt; this gene is an exception to the pattern with a CDS length greater than 6600 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. The encoded protein is mainly intracellular and localizes in the paranuclear compartment. It is synthesized as a preproprotein, and when the propeptide is still attached, no binding occurs to the VPS10 domain. This gene is strongly expressed in the central nervous system. 基因符号 - gp250
- SORL1
- LR11
- LRP9
- SorLA
- SORLA
- SorLA-1
UniProt编号 - Q92673
UniProt汇总 FUNCTION: SwissProt: Q92673 # Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction.
SIZE: 2214 amino acids; 248441 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to Ref.1, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to Ref.2, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
PTM: The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases.
SIMILARITY: SwissProt: Q92673 ## Contains 5 BNR repeats. & Contains 1 EGF-like domain. & Contains 6 fibronectin type-III domains. & Contains 11 LDL-receptor class A domains. & Contains 5 LDL-receptor class B repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
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