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  • merck millipore,默克密理博,AB5926,Anti-Potassium Channel Kv1.4 Antibody

  • merck millipore,默克密理博,AB5926,Anti-Potassium Channel Kv1.4 Antibody

    产品名称：Anti-Potassium Channel Kv1.4 Antibody
    产品型号：AB5926
    Detect Potassium Channel Kv1.4 using this Anti-Potassium Channel Kv1.4 Antibody validated for use in IC, IH, IP & WB.

    merck millipore,默克密理博,AB5926,Anti-Potassium Channel Kv1.4 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5926,Anti-Potassium Channel Kv1.4 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHC, WB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5926
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel Kv1.4 Antibody
    产品信息
    格式 Affinity Purified
    演示 Liquid. Buffer = 0.1M Phosphate buffer saline, pH 7.4. Contains no preservative.
    应用
    应用 Detect Potassium Channel Kv1.4 using this Anti-Potassium Channel Kv1.4 Antibody validated for use in IC, IH, IP & WB.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunoblotting

    Immunocytochemistry

    Immunohistochemistry on 4% paraformaldehyde fixed tissues.

    Immunoprecipitation

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to the N-terminus of rat Kv1.4.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Kv1.4
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002233.2
    Entrez基因汇总 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
    基因符号
    • HK1
    • KCNA4
    • HPCN2
    • KV1.4
    • HBK4
    • PCN2
    • HUKII
    • Kv1.4
    • KCNA4L
    • KCNA8
    UniProt编号
    • P22459
    UniProt汇总 FUNCTION: SwissProt: P22459 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    SIZE: 653 amino acids; 73288 Da
    SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with OPRS1 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DOMAIN: SwissProt: P22459 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5926,Anti-Potassium Channel Kv1.4 Antibody

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