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  • merck millipore,默克密理博,AB5908-200UL,Anti-Potassium Channel HERG Antibody, CT

  • merck millipore,默克密理博,AB5908-200UL,Anti-Potassium Channel HERG Antibody, CT

    产品名称：Anti-Potassium Channel HERG Antibody, CT
    产品型号：AB5908-200UL
    Anti-Potassium Channel HERG Antibody, C-terminus is an antibody against Potassium Channel HERG for use in IC, IP & WB.

    merck millipore,默克密理博,AB5908-200UL,Anti-Potassium Channel HERG Antibody, CT

  • 产品介绍
  • merck millipore,默克密理博,AB5908-200UL,Anti-Potassium Channel HERG Antibody, CT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5908-200UL
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Potassium Channel HERG Antibody, CT
    Alternate Names
    • Kcnh2
    • Erg1
    产品信息
    格式 Affinity Purified
    控制
    • CONTROL ANTIGEN: Included free of charge with the antibody is 120 μg of fusion protein (35 kD). The stock solution of the antigen can be made up using 100 μL of PBS. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. For positive control, use 20 ng of fusion protein per lane. Optimal concentrations must be determined by the end user.
    演示 Affinity Purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 200 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
    应用
    应用 Anti-Potassium Channel HERG Antibody, C-terminus is an antibody against Potassium Channel HERG for use in IC, IP & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot: 1:200-400 using ECL on HERG transfected HEK293 cells.

    Immunocytochemistry

    Immunoprecipitation

    Dilutions should be made using a carrier protein such as BSA (1-3%)

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 GST fusion protein corresponding to amino acids 1106-1159 of human erg1 (HERG) (Accession number Q12809).
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes HERG (hKv11.1, Voltage gated K+ channel subfamily H member 2, KCNH2, ether-a-go-go related channel). The antibody recognizes the HERG1b splice variant but not splice variants HERG1-3 or HERG-4. The immunogen shares similiarity with rat erg2 (22/54) and rat erg3 (21/54).
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_172057.1
    • NM_000238.2
    • NM_172056.1
    Entrez基因汇总 This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
    基因符号
    • ERG
    • KCNH2
    • ERG1
    • LQT2
    • erg1
    • HERG
    • SQT1
    • H-ERG
    • Kv11.1
    • HERG1
    • Erg1
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q12809
    UniProt汇总 FUNCTION: SwissProt: Q12809 # Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
    SIZE: 1159 amino acids; 126655 Da
    SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2 and KCNH7/ERG3. Interacts with ALG10B (By similarity). Heteromultimer with KCNE1 and KCNE2.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Highly expressed in heart and brain.
    DOMAIN:SwissProt: Q12809 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
    PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
    DISEASE: SwissProt: Q12809 # Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:152427]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2. & Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.
    SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB5908-200UL,Anti-Potassium Channel HERG Antibody, CT

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