merck millipore,默克密理博,681668,Wnt Synergist, QS11 - CAS 944328-88-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,681668,Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem

经验配方	CAS号
C₃₆H₃₃N₅O₂	944328-88-5

描述
概述	A cell-permeable purine compound that binds ARFGAPs (K_d = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
产品目录编号	681668
品牌系列	Calbiochem®
同义词	QS11, Wnt Pathway Activator II

参考
参考	Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO or EtOH

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Regulatory Review
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,681668,Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem

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