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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5886-50UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Caspr2 Antibody Alternate Names - Contactin-Associated Protein-like 2
产品信息 格式 Affinity Purified 控制 - CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen. The stock solution of the antigen can be made up using 100 μL of sterile distilled water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 应用 应用 Anti-Caspr2 Antibody is an antibody against Caspr2 for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000 using ECL on rat brain membranes.
Dilutions should be made using a carrier protein such as BSA (1-3%)
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding amino acids 1315-1331 of human Caspr2 (Accession number NP 054860). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Caspr2 (Contactin-Associated Protein 2). The epitope does not share homology with any other known proteins.
SPECIES REACTIVITIES: It is expected that the antibody will also react with mouse due to identical sequence homology. Other species have not been tested.品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_014141.4
Entrez基因汇总 This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness. 基因符号 - CDFE
- CNTNAP2
- DKFZp781D1846
- CASPR2
- KIAA0868
- Caspr2
- NRXN4
UniProt编号 - Q9UHC6
UniProt汇总 FUNCTION: SwissProt: Q9UHC6 # May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.
SIZE: 1331 amino acids; 148167 Da
SUBUNIT: Associates with KCNA2 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Predominantly expressed in nervous system.
DISEASE: SwissProt: Q9UHC6 # Defects in CNTNAP2 are the cause of cortical dysplasia- focal epilepsy syndrome (CDFE syndrome) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
SIMILARITY: SwissProt: Q9UHC6 ## Belongs to the neurexin family. & Contains 2 EGF-like domains. & Contains 1 F5/8 type C domain. & Contains 4 laminin G-like domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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