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merck millipore,默克密理博,FCMAB420F,Milli-Mark Anti-PKCα-FITC Antibody, clone M4
产品名称：Milli-Mark Anti-PKCα-FITC Antibody, clone M4
产品型号：FCMAB420F
This Milli-Mark Anti-PKCα-FITC Antibody, clone M4 is validated for use in FC for the detection of PKCα.
merck millipore,默克密理博,FCMAB420F,Milli-Mark Anti-PKCα-FITC Antibody, clone M4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, H FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB420F 商名 - Milli-Mark
描述 Milli-Mark® Anti-PKCα-FITC Antibody, clone M4 Alternate Names - protein kinase C, alpha
- aging-associated gene 6
- protein kinase C alpha type
背景信息 Protein Kinase c alpha (PKC alpha) is a 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell-cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy-terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation. 产品信息 格式 FITC 控制 - A431 cells
演示 Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 This Milli-Mark Anti-PKCα-FITC Antibody, clone M4 is validated for use in FC for the detection of PKCα. 主要应用 - Flow Cytometry
生物信息 免疫原品种 PKCα purified from rabbit brain cytosol. 克隆 M4 宿主 Mouse 特异性 Antibody recognizes PKCα. 同种型 IgG1 品种反应性 RabbitHuman Species Reactivity Note Shown to work on Human. Predicted to work on rabbit based on immunogen design. Unconjugated antibody (Cat No. 05-154) was shown to work on Rat, Bovine, and Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001095194
Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. 基因符号 - MGC129901
- PRKCA
- PKC-A
- AAG6
- PKC-alpha
纯化方法 Protein G Purified UniProt编号 - P10102
UniProt汇总 FUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 672 amino acids; 76764 Da
SUBUNIT: Interacts with CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
SIMILARITY: SwissProt: P17252 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by flow cytometry using A431 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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