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merck millipore,默克密理博,AB5674P,Anti-Acid Sensitive Ion Channel 1 Antibody
产品名称：Anti-Acid Sensitive Ion Channel 1 Antibody
产品型号：AB5674P
Detect Acid Sensitive Ion Channel 1 using this Anti-Acid Sensitive Ion Channel 1 Antibody validated for use in ELISA & WB.
merck millipore,默克密理博,AB5674P,Anti-Acid Sensitive Ion Channel 1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB, ELISA Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5674P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Acid Sensitive Ion Channel 1 Antibody Alternate Names - Amiloride-sensitive Cation Channel 2
- ASIC1
- BNC1
- MDEG
- BNaC1a
产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid in phosphate buffered saline containing 0.1% BSA. 应用 应用 Detect Acid Sensitive Ion Channel 1 using this Anti-Acid Sensitive Ion Channel 1 Antibody validated for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blot: 1-10 μg/mL using ECL.
Immunohistochemistry: not tested. It is recommended that the antibody be tried at 1-20 μg/mL on paraformaldehyde fixed tissue.
ELISA: 0.5-1 μg/mL using 1 μg/mL control peptide (Catalog number AG394) per well.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A 20 amino acid peptide sequence near the extracellular N-terminus of rat ASIC1 (Chen et al. 1998; Waldmann et al. 1997; Garcia-Anoveros et al. 1997; Waldmann et al. 1996).
The immunogen sequence has 100% homology with human sodium channel 2 or BNaC2.浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes rat Acid Sensitive Ion Channel 1 (ASIC1). The immunogen shows no significant sequence homology with ASIC-beta or other ASICs. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_020039.2
- NM_001095.2
Entrez基因汇总 This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products. 基因符号 - BNAC2
- ACCN2
- BNaC2
- ASIC1A
- hBNaC2
- ASIC1
- ASIC
UniProt编号 - P78348
UniProt汇总 FUNCTION: SwissProt: P78348 # Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear (By similarity).
SIZE: 528 amino acids; 59967 Da
SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and ACCN1 (By similarity). Interacts with PRKCABP.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity).
TISSUE SPECIFICITY: Expressed in most or all neurons.
PTM: Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.
SIMILARITY: SwissProt: P78348 ## Belongs to the amiloride-sensitive sodium channel family.
MISCELLANEOUS: Potentiated by Ca(2+), Mg(2+), Ba(2+) and multivalent cations. Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Potentiated by FMRFamide-related neuropeptides. PH dependence may be regulated by serine proteases.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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