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merck millipore,默克密理博,420360,KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
产品名称：KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
产品型号：420360
The KMO Inhibitor I, Ro 61-8048, also referenced under CAS 199666-03-0, controls the biological activity of KMO. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,420360,KMO Inhibitor I, Ro 61-8048 - CAS 199666-03-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₁₅N₃O₆S₂ 199666-03-0 描述 概述 A cell-permeable thiazolylbenzenesulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki = 4.8 nM; IC50 = 37 nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available (Cat. No. 420361). 产品目录编号 420360 品牌系列 Calbiochem®
同义词 Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048, 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide, Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048, Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide 参考 参考 Campesan, S., et al. 2011. Chem. Biol. 21, 961.
Zwilling, D., et al. 2011. Cell 145, 863.
Giorgini, F., et al. 2005. Nat. Genet. 37, 526.
Cozzi, A.,. et al. 1999. J. Cereb. Blood Flow Metab. 19, 771,
Rover, S., et al. 1997. J. Med. Chem. 40, 4378.产品信息 CAS号 199666-03-0 形式 Yellow solid Hill配方 C₁₇H₁₅N₃O₆S₂ 化学配方 C₁₇H₁₅N₃O₆S₂ Molar Mass 421.5 结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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