merck millipore,默克密理愽
  • merck millipore,默克密理博,516570,PPARγ Modulator, SR1664 - Calbiochem

  • merck millipore,默克密理博,516570,PPARγ Modulator, SR1664 - Calbiochem

    产品名称：PPARγ Modulator, SR1664 - Calbiochem
    产品型号：516570
    A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated γ (PPAR-γ) receptor, but does not exhibit any transcriptional agonism.

    merck millipore,默克密理博,516570,PPARγ Modulator, SR1664 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,516570,PPARγ Modulator, SR1664 - Calbiochem

    重要规格表

    经验配方
    C₃₃H₂₉N₃O₅
    描述
    概述 A cell-permeable non-thiazolidinediones derivative that binds tightly to peroxisome proliferator-activated γ (PPAR-γ) receptor (Ki = 29 nM; IC50 = 80 nM), but does not exhibit any transcriptional agonism. Unlike TZD compounds, it does not induce weight gain or diminish hematocrit. Shown to effectively block CDK-5-mediated phosphorylation of Ser273 of PPAR-gamma in adipose tissue. Supresses hepatic glucose production, reduces plasma free fatty acid levels, and improves insulin sensitivity of adipose tissue.
    产品目录编号 516570
    品牌系列 Calbiochem®
    同义词 (S)-4'-((2,3-dimethyl-5-(1-(4-nitrophenyl)ethylcarbamoyl)-1H-indol-1-yl)methyl)biphenyl-2-carboxylic acid
    参考
    参考 Choi, J., et al. 2011, Nature 477, 477.
    产品信息
    形式 Red solid
    Hill配方 C₃₃H₂₉N₃O₅
    化学配方 C₃₃H₂₉N₃O₅
    Molar Mass 547.6
    结构配方图像
    生物信息
    纯度 ≥92% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,516570,PPARγ Modulator, SR1664 - Calbiochem

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