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经验配方 CAS号 C₂₀H₂₄O₂ 1191-85-1 描述 概述 Cell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. Also acts as a potent modulator of Ca2+ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells. 产品目录编号 434741 品牌系列 Calbiochem®
同义词 5,8,11,14-Eicosatetraynoic Acid 参考 参考 Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.产品信息 CAS号 1191-85-1 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₂₀H₂₄O₂ 化学配方 C₂₀H₂₄O₂ Molar Mass 296.4 可逆 N 结构配方图像 生物信息 主靶 PLA₂ 主靶IC50 8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells 纯度 ≥95% by TLC 理化信息 细胞可渗透 Y 溶解度 EtOH or DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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