• merck millipore,默克密理博,434741,ETYA - CAS 1191-85-1 - Calbiochem
  • merck millipore,默克密理博,434741,ETYA - CAS 1191-85-1 - Calbiochem

    产品名称:ETYA - CAS 1191-85-1 - Calbiochem
    产品型号:434741
    Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases.

    merck millipore,默克密理博,434741,ETYA - CAS 1191-85-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,434741,ETYA - CAS 1191-85-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₂₄O₂1191-85-1
    描述
    概述 Cell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A2 (PLA2) and cytochrome P-450. Inhibits cyclooxygenase (ID50 = 8 µM), 5-lipoxygenase (ID50 = 10 µM), 12-lipoxygenase (ID50 = 300 nM), and 15-lipoxygenase (ID50 = 200 nM) in whole cells. Also acts as a potent modulator of Ca2+ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
    产品目录编号 434741
    品牌系列 Calbiochem®
    同义词 5,8,11,14-Eicosatetraynoic Acid
    参考
    参考 Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol. 19, 680.
    Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
    Ondrey, F., et al. 1989. Cancer Res. 49, 1138.
    Kuhn, H., et al. 1984. Eur. J. Biochem. 139, 577.
    产品信息
    CAS号 1191-85-1
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₂₀H₂₄O₂
    化学配方 C₂₀H₂₄O₂
    Molar Mass 296.4
    可逆 N
    结构配方图像
    生物信息
    主靶 PLA₂
    主靶IC50 8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
    纯度 ≥95% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 EtOH or DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,434741,ETYA - CAS 1191-85-1 - Calbiochem

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