merck millipore,默克密理博,AB5601,Anti-RAGE Antibody, CT

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merck millipore,默克密理博,AB5601,Anti-RAGE Antibody, CT
产品名称：Anti-RAGE Antibody, CT
产品型号：AB5601
This Anti-RAGE Antibody, C-terminus is validated for use in ELISA, IH for the detection of RAGE.

merck millipore,默克密理博,AB5601,Anti-RAGE Antibody, CT

产品介绍

merck millipore,默克密理博,AB5601,Anti-RAGE Antibody, CT

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, ELISA	Gt	Serum	Polyclonal Antibody

描述
产品目录编号	AB5601
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-RAGE Antibody, CT
背景信息	RAGE is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

产品信息
格式	Serum
演示	Goat serum. Liquid. Containing 0.01% thimerosal.

应用
应用	This Anti-RAGE Antibody, C-terminus is validated for use in ELISA, IH for the detection of RAGE.
主要应用	Immunohistochemistry ELISA
应用说明	Immunohistochemistry: > 1:200 on paraffin embedded tissue sections. The antibody reacts well with human diabetic kidney. The antibody may show better reactivity after performing antigen retrieval by the citrate buffer/pressure cooker method. ELISA: > 1:5,000 Optimal working dilutions must be determined by the end user.

生物信息
免疫原品种	Synthetic peptide from the C-terminus of human RAGE, amino acids 385 to 399. {RAELNQSEEPEAGES}.
表位	C-terminus
宿主	Goat
特异性	Specific for Receptor of Advanced Glycosylated End Products (RAGE). This antibody immunolabels vessels from diabetic tissues in formalin-fixed paraffin sections.
品种反应性	Human
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_014226.1
基因符号	EC 2.7.11.22 RAGE RAGE-1 RAGE1 MOK
UniProt编号	Q9UQ07
UniProt汇总	FUNCTION: SwissProt: Q9UQ07 # Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity). SIZE: 419 amino acids; 48014 Da SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina. PTM: Autophosphorylated (By similarity). SIMILARITY: SwissProt: Q9UQ07 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.

储存和货运信息

存储条件

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.

During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.