merck millipore,默克密理博,400012,Caspase-1 Inhibitor II - CAS 178603-78-6

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merck millipore,默克密理博,400012,Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem
产品名称：Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem
产品型号：400012
The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

merck millipore,默克密理博,400012,Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

产品介绍

merck millipore,默克密理博,400012,Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem

重要规格表

经验配方	CAS号
C₂₄H₃₃ClN₄O₈	178603-78-6

描述
概述	A cell-permeable and irreversible inhibitor of caspase-1 (K_i = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
产品目录编号	400012
品牌系列	Calbiochem®
同义词	IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK

参考
参考	Brenner, B., et al. 1998. Cell Death Differ. 5, 29. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608. Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895. Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Enari, M., et al. 1995. Nature 375, 78. Walker, N.P.C., et al. 1994. Cell 78, 343. Thornberry, N., et al. 1992. Nature 356, 768.

参考

Brenner, B., et al. 1998. Cell Death Differ. 5, 29.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Enari, M., et al. 1995. Nature 375, 78.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Thornberry, N., et al. 1992. Nature 356, 768.

产品信息
CAS号	178603-78-6
具有ATP竞争性	N
形式	White solid
Hill配方	C₂₄H₃₃ClN₄O₈
化学配方	C₂₄H₃₃ClN₄O₈
Molar Mass	541.0
肽序列	Ac-Tyr-Val-Ala-Asp-CMK
可逆	N
结构配方图像

生物信息
主靶	caspase-1
主靶K_i	760 pM against caspase-1
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO
肽序列	Ac-Tyr-Val-Ala-Asp-CMK

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.