- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, Ht, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-169 品牌系列 Upstate
商名 - Upstate
描述 Anti-iPLA2 Antibody 产品信息 格式 Affinity Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, and 5mg/ml BSA before the addition of glycerol to 30% 应用 应用 Anti-iPLA2 Antibody detects level of iPLA2 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 681-691 (CTDPDGRAVDR) of mouse iPLA2 and of the short isoform of human iPLA2 (calcium-independent phospholipase A2), and 735-745 of the long isoform of human iPLA2 宿主 Rabbit 特异性 iPLA2 同种型 IgG 品种反应性 RatHumanHamsterMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003560
Entrez基因汇总 The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date. 基因符号 - iPLA2
- PLA2G6
- PNPLA9
- PLA2
- OTTHUMP00000028877
- INAD1
- IPLA2
- GVI
- CaI-PLA2
纯化方法 Immunoaffinity chromatography UniProt编号 - O60733
UniProt汇总 FUNCTION: SwissProt: O60733 # Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
SIZE: 806 amino acids; 89903 Da
SUBUNIT: Forms large oligomeric 270-350 kDa structures.
SUBCELLULAR LOCATION: Isoform LH-iPLA2: Membrane; Peripheral membrane protein. & Isoform SH-iPLA2: Cytoplasm.
TISSUE SPECIFICITY: Four different transcripts were found to be expressed in a distinct tissue distribution.
DISEASE: SwissProt: O60733 # Defects in PLA2G6 are a cause of neurodegeneration with brain iron accumulation (NBIA) [MIM:610217]. NBIA comprises a clinically and genetically heterogeneous group of disorders with high basal ganglia iron. & Defects in PLA2G6 are the cause of infantile neuroaxonal dystrophy 1 (INAD1) [MIM:256600]; also known as Seitelberger disease. Infantile neuroaxonal dystrophy (INAD) is a neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. & Defects in PLA2G6 are the cause of Karak syndrome [MIM:608395]. Karak syndrome is a neurologic disease characterized by early-onset progressive cerebellar ataxia, dystonia, spasticity, intellectual and features compatible with iron deposition in the putamen and substantia nigra.
SIMILARITY: SwissProt: O60733 ## Contains 7 ANK repeats.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from rat RINB2 insulinoma cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,SF-3609,PMS2 ; Human, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem
相关产品
merck millipore,默克密理博,70073,pET-30 Xa/LIC Vector Kit - Novagen
merck millipore,默克密理博,400012,Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem
merck millipore,默克密理博,MAB2059,Anti-Integrin β4 Antibody, clone ASC-8
merck millipore,默克密理博,SF-3609,PMS2 ; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,197224,Bcr-abl Inhibitor III, GNF-5 - Calbiochem
merck millipore,默克密理博,AB5601,Anti-RAGE Antibody, CT
merck millipore,默克密理博,MABT118,Anti-Desmoglein-1 Antibody, clone 32-2B
merck millipore,默克密理博,0500-2880,Guava easyCyte 8HT Service Total 2 year plan
merck millipore,默克密理博,04-434,Anti-Bax Antibody, rabbit monoclonal