merck millipore,默克密理博,04-434,Anti-Bax Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-434,Anti-Bax Antibody, rabbit monoclonal
产品名称：Anti-Bax Antibody, rabbit monoclonal
产品型号：04-434
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Bax Antibody, Rabbit is validated for use More>>

merck millipore,默克密理博,04-434,Anti-Bax Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-434,Anti-Bax Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-434
品牌系列	Upstate
商名	Upstate
描述	Anti-Bax Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Bax Antibody, Rabbit is validated for use in IP, WB, IH(P) for the detection of Bax.
主要应用	Western Blotting
应用说明	Immunoblot Analysis: A 1:2,000 dilution of the lot detected endogenous Bax in lysate from Hela cells. Immunoprecipitation: A 1:100 dilution of this antibody immunoprecipitated Bax using protein G:agarose beads. Immunohistochemistry: 1:250 of this antibody was used in Immunohistochemical analysis of Paraffin-embedded human lymph node.

生物信息
免疫原品种	Synthetic peptide corresponding to amino acid residues near the dimerisation domain of human Bax.
宿主	Rabbit
特异性	Recognizes a region near the dimerisation domain of human Bax.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_138765.2 NM_004324.3 NM_138761.2 NM_138763.2 NM_138764.2
Entrez基因汇总	The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
基因符号	BAX
UniProt编号	Q07814
UniProt汇总	FUNCTION: SwissProt: Q07814 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor Bcl-2 or its adenovirus homolog E1B 19k protein.\| Q07812 # Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis. SIZE: 41 amino acids; 4678 Da SUBUNIT: Interacts with HN. SUBCELLULAR LOCATION: Cytoplasm. DOMAIN: SwissProt: Q07815 DISEASE:SwissProt: Q07812 # Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and plasmacytoma. SIMILARITY: SwissProt: Q07815 ## Belongs to the Bcl-2 family. \| Q07814 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.# Belongs to the Bcl-2 family. \| P55269 ## Belongs to the Bcl-2 family. \| Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity).# Belongs to the Bcl-2 family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.